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Diagnosis and Management of Kidney Injury Following HSCT Refined

Virginia Powers, PhD
Published: Thursday, Apr 04, 2019

Sangeeta R. Hingorani, MD, MPH

Sangeeta R. Hingorani, MD, MPH

Kidney complications often occur following successful hematopoietic stem cell transplantation (HSCT) from a myriad of underlying etiologies, according to up-to-date information provided during an educational session at the 2019 European Society for Blood and Marrow Transplantation Annual Meeting.

Sangeeta R. Hingorani, MD, MPH, professor of pediatrics at the University of Washington, and director of Nephrology at Seattle Children’s Hospital, charted the course of kidney injury from the toxic lesion to transplant-associated thrombotic microangiopathy (TA-TMA).

She began her discussion of kidney injury with a case study of a 25-year-old man who gained 8 kg between days +3 to +7 following myeloablative allogeneic HSCT for acute myeloid leukemia (AML). Day +7 saw a bilirubin rise to 2.1 mg/dL, which continued to rise. The patient showed jaundice and had right upper quadrant tenderness plus ascites. An ultrasound of the liver showed reversal of flow; however, urinalysis was negative but creatinine had doubled from baseline.

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