Rosa Hwang, MD
An investigational antibody directed against Dickkopf-3 (DKK3
) may be the key in suppressing tumor growth and extending survival in patients with pancreatic adenocarcinoma, according to a recent preclinical study published in Science Translational Medicine
expression was determined to promote growth of pancreatic ductal adenocarcinoma, metastasis, and resistance to systemic therapies. By targeting the gene in an autochthonous model, researchers were able to stop tumor growth, induce CD3+
T cells, and double survival rates.
stimulates cancer growth, metastasis, and resistance to chemotherapy and immunotherapy,” said Rosa Hwang, MD, lead author and professor at The University of Texas MD Anderson Cancer Center. “Targeting DKK3
in a pancreatic cancer mouse model boosted immune cell infiltration and more than doubled survival.”
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