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DKK3 Gene Linked to Pancreatic Adenocarcinoma Proliferation

Caroline Seymour
Published: Wednesday, Dec 12, 2018

Rosa Hwang, MD

Rosa Hwang, MD

An investigational antibody directed against Dickkopf-3 (DKK3) may be the key in suppressing tumor growth and extending survival in patients with pancreatic adenocarcinoma, according to a recent preclinical study published in Science Translational Medicine.1,2

DKK3 expression was determined to promote growth of pancreatic ductal adenocarcinoma, metastasis, and resistance to systemic therapies. By targeting the gene in an autochthonous model, researchers were able to stop tumor growth, induce CD3+ and CD8+ T cells, and double survival rates.

DKK3 stimulates cancer growth, metastasis, and resistance to chemotherapy and immunotherapy,” said Rosa Hwang, MD, lead author and professor at The University of Texas MD Anderson Cancer Center. “Targeting DKK3 in a pancreatic cancer mouse model boosted immune cell infiltration and more than doubled survival.”

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