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EU Approves Daratumumab Triplets for Myeloma

Jason M. Broderick @jasoncology
Published: Monday, May 01, 2017

Jan van de Winkel, PhD

Jan van de Winkel, PhD

The European Commission (EC) has approved daratumumab (Darzalex) for use in combination with lenalidomide (Revlimid) and dexamethasone or bortezomib (Velcade) and dexamethasone for the treatment of patients with multiple myeloma following at least 1 prior therapy, based primarily on findings from the phase III POLLUX and CASTOR studies.1,2 

Daratumumab was previously approved by the EC as a monotherapy for the treatment of adult patients with relapsed/refractory multiple myeloma whose prior therapy included a proteasome inhibitor and an immunomodulatory agent.
  1. Dimopoulos MA, Oriol A, Nahi H, et al. Daratumumab, lenalidomide, and dexamethasone for multiple myeloma. N Engl J Med. 2016;375(14):1319-1331.
  2. Palumbo A, Chanan-Khan A, Weisel K, et al. Daratumumab, bortezomib, and dexamethasone for multiple myeloma. N Engl J Med. 2016;375(8):754-766.

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