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Expert Discusses Long-Term Dabrafenib/Trametinib Data in Melanoma

Angelica Welch
Published: Thursday, Aug 10, 2017

Georgina Long, MD

Georgina Long, MD
At the 2017 ASCO Annual Meeting, investigators reported 5-year follow-up data from a phase II study of dabrafenib (Tafinlar) plus trametinib (Mekinist) in patients with BRAF V600-mutant unresectable or metastatic melanoma.

OncLive: Could you provide an overview of this long-term follow-up?

Long: For the dabrafenib and trametinib phase I/II study, we are now reporting the 5-year PFS and OS. Overall, 13% of patients are progression-free at 5 years, which is pretty significant. When we turn to the OS, we know that about 28% of patients are still alive at 5 years. If we look at the subgroup that have less than 3 metastatic sites and a normal LDH at best line, the figures are even better. We have an OS of 51%...so pretty significant—that is more than half of the patients with lower burden of disease and lower LDH alive at 5 years having been treated with dabrafenib/trametinib. These are actually the same subset of patients that do very well long term on immunotherapy, as well.
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View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Advances in™ Melanoma: Exploring BRAF/MEK in Adjuvant and Neoadjuvant SettingsSep 28, 20191.5
Medical Crossfire®: What Does Data Tell Us About How to Optimize Checkpoint Inhibitor Strategies Across Lines of Care for Patients with Melanoma?Nov 30, 20191.5
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