News >

Expert Discusses State of Follicular Lymphoma Treatment in 2017

Danielle Bucco
Published: Thursday, Apr 13, 2017

Nathan Fowler, MD

Nathan Fowler, MD

Over the past 25 years, new regimens for follicular lymphoma have led to better overall survival; however, outcomes often dramatically vary among patients receiving the same standard treatment, such as R-CHOP.

, Fowler, an associate professor of Lymphoma/Myeloma at The University of Texas MD Anderson Cancer Center, discussed the current management of high-risk follicular lymphoma and ongoing developments in the field.

OncLive: Can you discuss the current management of high-risk follicular lymphoma?

Fowler: We've known for quite some time that patients with follicular lymphoma behave differently when treated with the same therapy. Patients can get a standard therapy, such as R-CHOP and have dramatically different outcomes. In fact, some patients with the same therapy could have a median survival of around 3 to 5 years, whereas others have a median survival of 14 years.

Finally, we should not ignore methods of autologous stem cell transplant. It's been clear that if you take a patient who is refractory to one line of chemotherapy, this does not necessarily predict long-term poor outcomes. In fact, retrospective data, looking at patients who underwent a transplant, suggested that even patients who had short remissions could experience prolonged survival. Around 60% of patients following autologous transplant will have a long-term remission.   

When a patient is initially diagnosed, what are some of the factors that could predict whether they will have a worse outcome?

In patients who are initially diagnosed, we know that certain clinical factors do predict patients who have a worse outcome. The FLIPI scoring system can at least accurately predict the outcome of those groups of patients. The scoring system is based on hemoglobin, stage 3 or 4 disease, a number of nodal sites, the patient's age, and their LDH.

... to read the full story
To Read the Full Story

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: 22nd Annual International Congress on Hematologic Malignancies®: Focus on Leukemias, Lymphomas and MyelomaMay 30, 20192.0
Online Medical Crossfire®: 5th Annual Miami Lung Cancer ConferenceMay 30, 20196.5
Publication Bottom Border
Border Publication