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Expert Explains Individualized Decision on Endocrine Therapy Beyond 5 Years in Breast Cancer

Gina Columbus @ginacolumbusonc
Published: Monday, May 22, 2017

Amye J. Tevaarwerk, MD

Amye J. Tevaarwerk, MD

Endocrine therapy remains an integral part of the treatment paradigm for patients with estrogen receptor (ER)–positive breast cancer; however, questions remain on which patients should continue their therapy beyond 5 years.

State of the Science Summit on Metastatic Breast Cancer. In an interview, she discussed how physicians decide on extending endocrine therapy beyond 5 years for patients with ER-positive breast cancer, the tools she hopes will soon become available to help clarify this decision, and the clinical research in this population she is eagerly awaiting.

OncLive: What did you cover in your presentation on ER-positive breast cancer?

Tevaarwerk: In my talk, I focused on extended endocrine therapy and the current state of the art [approach], with regard to what we know currently and what we believe we should do after 5 years of endocrine therapy in patients with ER-positive breast cancer. 

What are the questions currently being asked when a patient has reached 5 years of endocrine therapy?

How did we get to the prior gold standard, which was to do 5 years of endocrine therapy and what was it that drove that thinking? It is always very important to consider what that data said. The current data seem to suggest that there may be circumstances for higher-risk individuals where we want to go for 5 years more [with endocrine therapy] and extend it to 10 years. There are a number of open questions. What patients are at a high-enough risk? What drugs will you use if you go more than 5 years? Are there really any tools for helping you pick out the patients you should consider doing that for?

Are there any data that suggest what patients to pick for extended therapy?

The current clinical trial data that we have looking at that, unfortunately, is of data and work that were started a long time ago where we may have set things up a little differently versus if we were doing those studies now.
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