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Expert Explains Treatment Approaches for MCL

Brandon Scalea
Published: Thursday, Nov 15, 2018

Simon Rule, MD

Simon Rule, MD, PhD
For young, fit patients with mantle cell lymphoma (MCL), the best frontline treatment approach could be observation, according to Simon Rule, MD, PhD.

Rule discussed the observational and active therapeutic approaches for patients with MCL.

OncLive: What is the current management for patients with MCL?

Rule: For younger patients, it is pretty well established that it is a high-dose cytarabine-based regimen. It is usually followed by a stem cell transplant, followed by rituximab maintenance. That is pretty much the standard. There are a number of different ways you can give high-dose cytarabine. 

What regimens are in development?

Of course, the drugs that have made the biggest impact in this disease are the BTK inhibitors. The question is if we need these drugs for the frontline treatment of younger patients. These patients are off drugs and living a normal quality of life. When they relapse—because everyone relapses—that is when we introduce these novel therapies.
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