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Expert Highlights RESPONSE Results With Ruxolitinib in Polycythemia Vera

Danielle Bucco
Published: Wednesday, Jan 10, 2018

Ruben Mesa, MD
Ruben Mesa, MD
Four-year follow-up data suggest that the majority of patients with polycythemia vera (PV) who responded to treatment with ruxolitinib (Jakafi) maintained those responses for up to 4 years, according to an analysis from the RESPONSE trial that was presented at the 2017 ASH Annual Meeting. Additionally, there were no new safety signals compared with the previous follow-up at 80 weeks.

during the 2017 ASH Annual Meeting, Mesa, director of the UT Health San Antonio Cancer Center, discussed the significance of the RESPONSE study for patients with PV.

OncLive: Please provide an overview of the RESPONSE trial.

Mesa: My colleagues and I presented the 4-year follow-up data from the RESPONSE study. The RESPONSE study investigated ruxolitinib as a second-line therapy for patients with PV. We demonstrated that, at 4-years of follow-up, the majority of patients remain on the therapy.

Overall, there are no unexpected long-term toxicities. The efficacy in terms of phelobotomy independence, control of spleen size, and improvements in symptoms is very durable. This is a very important study. There are no long-standing data regarding therapies in PV that have risen from a randomized clinical trial.

What is the potential for ruxolitinib in the first-line setting?

Ruxolitinib in PV is a very active drug. The decision to start looking at it in the second-line setting was appropriate to meet an unmet need. Based on the degree of efficacy, it certainly may have activity in the frontline setting.

We need to see which patients would be most appropriate in terms of their risk or their degree of burden. PV is heterogeneous and ruxolitinib is active in the frontline setting. An important question is, “Which patients are more appropriate?” Is it all patients or a select group who have more predictively problematic PV from the beginning?

What are the next steps following this research?

We are wondering if we should use ruxolitinib in earlier settings of PV. Are there individuals who have higher-risk features where we should consider any combination-type approaches?

Another agent that is active in PV is interferons. There have been some pilot studies that have shown that they are active together. There may be a benefit in progression-free survival or efficacy by using them in combination; that is another interesting area of research.

Can you give background on the Myeloproliferative Disorders-Research Consortium Protocol 111 global phase II trial?

The Myeloproliferative Disorders-Research Consortium is an National Cancer Institute-funded program. This was an international collaboration between myeloproliferative neoplasms (MPNs) centers focusing on research and clinical trials. The 111 study was a second-line trial on the use of interferon in high-risk patients with PV or essential thrombocythemia who are resistant to hydroxyurea.

At this meeting, we presented data showing high-rates of efficacy in the second-line setting at 65%. There was good improvement in disease-related symptoms, which we presented as a more in-depth analysis on the issues of quality of life. Also, the drug is clearly active in the second-line setting but there are low-grade toxicities that are not irrelevant in the setting of PV at interferon. That clearly came through in our analysis; local skin-site irritations, flu-like symptoms, and rare autoimmune conditions can arise with the use of interferon. 

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