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Expert Sheds Light on Rare Complement-Mediated Hematologic Disorders

Gina Columbus @ginacolumbusonc
Published: Thursday, May 18, 2017

Ronald S. Go, MD

Ronald S. Go, MD

Thrombotic microangiopathy (TMA) and paroxysmal nocturnal hemoglobinuria (PNH) are 2 of several rare hematologic disorders that, although not malignant, can lead to extreme complications for patients.

State of the Science Summit on Hematologic Malignancies.

OncLive: Can you provide some information on these rare disorders?

Go: My task was to talk about the complement-mediated hematologic diseases. It is not exactly cancer or malignancies, but these are not-so-common conditions that are seen in practice but can be very challenging to treat.

For PNH, the diagnosis is more straightforward. I spoke about how patients present and how they are diagnosed but went straight to how physicians treat these patients. 

Where exactly do these disorders stem from?

These are rare disorders. There are probably a couple hundred—if not less than 1000—overall cases in the country every year. Where do they come from? These are conditions in which the red cells are destroyed so there is hemolysis and platelets are consumed.
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