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FDA Approves Cabozantinib for Renal Cell Carcinoma

Jason M. Broderick @jasoncology
Published: Monday, Apr 25, 2016

Toni Choueiri, MD

Toni Choueiri, MD

The FDA has approved cabozantinib (Cabometyx) as a treatment for patients with advanced renal cell carcinoma (RCC) who have received prior antiangiogenic therapy.

“With today’s announcement, patients with previously treated advanced kidney cancer now have a new option, the first and only approved product demonstrated to help patients live longer while also delaying the progression of their cancer,” Michael M. Morrissey, PhD, president and chief executive officer of Exelixis, the manufacturer of cabozantinib, said in a statement. “We are proud to bring new hope to this community, who are looking for more therapies that can help extend lives. Exelixis is committed to making Cabometyx available to patients in need within the next couple weeks.
 
The FDA initially approved cabozantinib in November 2012 as a treatment for patients with metastatic medullary thyroid cancer.

Choueiri TK, Escudier B, Powles T, et al. Cabozantinib versus everolimus in advanced renal-cell carcinoma. N Engl J Med. 2015;373(19):1814-1823.



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