Sandra Horning, MD
The FDA has granted atezolizumab (Tecentriq) a breakthrough therapy designation for use in combination with bevacizumab (Avastin) as a first-line treatment for patients with advanced or metastatic hepatocellular carcinoma (HCC).
The ongoing phase III IMbrave150 study (NCT03434379) is comparing atezolizumab/bevacizumab with sorafenib (Nexavar) in the frontline setting for patients with locally advanced or metastatic HCC.
Stein S, Pishvaian MJ, Lee MS, et al. Safety and clinical activity of 1L atezolizumab + bevacizumab in a phase Ib study in hepatocellular carcinoma (HCC). J Clin Oncol. 2018;36 (suppl; abstr 4074).
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