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Final OS Analysis Confirms Cobimetinib/Vemurafenib Benefit in Melanoma

Jason M. Broderick @jasoncology
Published: Tuesday, Aug 09, 2016

Josina Reddy, MD, PhD

Josina Reddy, MD, PhD

Combination therapy with cobimetinib (Cotellic) and vemurafenib (Zelboraf) reduced the risk of death by 30% compared with vemurafenib alone in patients with BRAF-positive advanced melanoma, according to the final survival analysis of the phase III coBRIM study that has now been published in The Lancet Oncology.

 
Ascierto PAA, McArthur GAA, Dréno B, et al. Cobimetinib combined with vemurafenib in advanced BRAFV600-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial [published online July 29, 2016]. Lancet Oncol. http://dx.doi.org/10.1016/S1470-2045(16)30122-X.

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View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Advances in™ Melanoma: Exploring BRAF/MEK in Adjuvant and Neoadjuvant SettingsSep 28, 20191.5
Medical Crossfire®: What Does Data Tell Us About How to Optimize Checkpoint Inhibitor Strategies Across Lines of Care for Patients with Melanoma?Nov 30, 20191.5
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