Josina Reddy, MD, PhD
Combination therapy with cobimetinib (Cotellic) and vemurafenib (Zelboraf) reduced the risk of death by 30% compared with vemurafenib alone in patients with BRAF-positive advanced melanoma, according to the final survival analysis of the phase III coBRIM study that has now been published in The Lancet Oncology
Ascierto PAA, McArthur GAA, Dréno B, et al. Cobimetinib combined with vemurafenib in advanced BRAFV600-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial [published online July 29, 2016]. Lancet Oncol. http://dx.doi.org/10.1016/S1470-2045(16)30122-X.
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