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FLAURA Findings, Emerging Combos Advance EGFR+ NSCLC Landscape

Gina Columbus @ginacolumbusonc
Published: Thursday, Jan 11, 2018

Lecia V. Sequist, MD, MPH

Lecia V. Sequist, MD, MPH
2017 marked a year of highlights across the non–small cell lung cancer (NSCLC) field, with clinical advancements in both targeted therapies and immunotherapy. Focusing on EGFR-positive patients, the treatment paradigm seemingly transformed overnight with the release of the phase III FLAURA findings.

In an interview during the meeting, she reflected on the practice-changing osimertinib data, ongoing trials exploring combination regimens, and the hope that there might still be potential for immunotherapy in this patient subgroup.

OncLive: You spoke on targeted therapies and EGFR sequencing. What are some key things to note in this space?

Sequist: We saw some exciting data this year when it comes to EGFR-positive NSCLC with the FLAURA study, which was just recently presented at the 2017 ESMO Congress. In this randomized trial, they were looking at the third-generation T790M inhibitor osimertinib, which is usually given in the second-line setting after acquired resistance. In this trial, they were moving it up to the frontline setting and comparing it with standard of care—either erlotinib or gefitinib—and the trial showed that osimertinib has a much longer—almost double—median PFS, which was quite significant. In addition, this drug also has a much more tolerable safety profile. 
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