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Frontline Durvalumab/Tremelimumab Misses OS Endpoint in Metastatic NSCLC

Gina Columbus @ginacolumbusonc
Published: Wednesday, Aug 21, 2019

Jose Baselga, MD, PhD, executive vice president, Oncology R&D, AstraZenec

José Baselga, MD, PhD

The combination of durvalumab (Imfinzi) and tremelimumab did not improve overall survival (OS) compared with standard platinum-based chemotherapy in previously untreated patients with stage IV metastatic non–small cell lung cancer (NSCLC) who have tumor mutational burden (TMB) ≥20 mutations/megabase (mut/mB), missing the primary endpoint of the phase III NEPTUNE trial (NCT02542293).1



  1. Update on the Phase III NEPTUNE trial of Imfinzi plus tremelimumab in stage IV non-small cell lung cancer. AstraZeneca. Published August 21, 2019. Accessed August 21, 2019.
  2. Rizvi NA, Cho BC, Reinmuth N, et al. Durvalumab with or without tremelimumab vs platinum-based chemotherapy as first-line treatment for metastatic non-small cell lung cancer: MYSTIC. Ann Oncol. 2018;29(10). doi: 10.1093/annonc/mdy511.005.

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