David M. Gershenson, MD
Women with stage II to IV low-grade serous carcinoma of the ovary or peritoneum who received hormonal maintenance therapy after primary treatment had significantly longer progression-free survival (PFS) compared with women who underwent routine observation, according to a retrospective database study published in the Journal of Clinical Oncology.
In his interview, Gershenson, a professor of gynecologic oncology at The University of Texas MD Anderson Cancer Center, discusses the results for the retrospective study and the next steps going forward.
OncLive: Can you provide an overview of the study?
: This is a retrospective database study of women who have this rare subtype of ovarian cancer. We analyzed a total of 203 women, 133 of whom had been treated with primary cytoreductive surgery for stage II, III, or IV, low-grade serous carcinoma, followed by platinum-based chemotherapy and then surveillance. We compared that to 70 women who had the same treatment surgery followed by platinum-based chemotherapy, but were then placed on hormonal maintenance therapy with one of the antiestrogens that are used for breast cancer, such as aromatase inhibitors or tamoxifen.
I think the main message of this study was that there was a very significant difference in PFS that favored the women who received a hormonal maintenance therapy and we believe that it is potentially practice changing. We're in the process of trying to develop a randomized clinical trial to confirm our findings.
What are the next steps regarding this study?
We work through NRG Oncology, which is an NCI-sponsored cooperative group and we are trying to partner with international colleagues. The study that is in development is a randomized phase III study that would take the same patients with stage II, III, or IV low-grade serous carcinoma of the ovary or peritoneum. They would all undergo primary cytoreductive surgery followed by platinum-based chemotherapy and that generally would be carboplatin and paclitaxel although there are some variations on that theme.
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