Adding IV hydrocortisone (HCT) to standard dexamethasone (DXM) prophylaxis reduced the incidence of hypersensitivity reactions (HSR) in women undergoing paclitaxel-based treatment for gynecologic cancers.
Patients discontinued treatment if they manifested paclitaxel HSRs of grade ≥3 or stopped receiving paclitaxel because of intentional change of chemotherapy regimen for clinical reasons such as tumor nonresponse.
Jeerakornpassawat D, Suprasert P. Randomized, controlled trial of dexamethasone versus dexamethasone plus hydrocortisone as prophylaxis for hypersensitivity reactions due to paclitaxel treatment for gynecologic cancer. Int J Gynecol Cancer. Int J Gynecol Cancer. 2017;27(8):1794-1801 doi: 10.1097/IGC.0000000000001069.
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