Meletios Dimopoulos, MD
Single-agent ibrutinib (Imbruvica) induced a response rate of 90% at a median follow-up of 18.1 months in rituximab-refractory patients with Waldenstrom macroglobulinemia, according to results from an open-label substudy of the ongoing phase III iNNOVATE trial published in The Lancet Oncology
Common grade 3 adverse events that experienced included neutropenia in 4 patients (13%), hypertension in 3 patients (10%), and anemia, thrombocytopenia, and diarrhea in 2 patients each (6%). There were 10 patients (32%) who experienced serious adverse events, which were most often infections. Overall, 26 patients (84%) continued ibrutinib at the time of the report, while 3 patients discontinued due to progression and 2 discontinued due to adverse events.
Dimopoulos MA, Trotman J, Tedeschi A, et al. Ibrutinib for patients with rituximab-refractory Waldenstrom's macroglobulinaemia (iNNOVATE): an open-label substudy of an international, multicentre, phase 3 trial. The Lancet Oncology. 2017;18(2):241-250. doi:10.1016/s1470-2045(16)30632-5.
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