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Ibrutinib Combo Improves PFS in Waldenstrom Macroglobulinemia

Jason M. Broderick @jasoncology
Published: Tuesday, Dec 05, 2017

Meletios Dimopoulos, MD

Meletios Dimopoulos, MD
The combination of ibrutinib (Imbruvica) plus rituximab (Rituxan) improved progression-free survival (PFS) versus rituximab alone in patients with Waldenström macroglobulinemia enrolled in the phase III iNNOVATE (PCYC-1127) trial.

The FDA approved single-agent ibrutinib for patients with WM in January 2015, based on results from a phase II study.
Dimopoulos MA, Trotman J, Tedeschi A, et al. Ibrutinib for patients with rituximab-refractory Waldenstrom's macroglobulinaemia (iNNOVATE): an open-label substudy of an international, multicentre, phase 3 trial. The Lancet Oncology. 2017;18(2):241-250. doi:10.1016/s1470-2045(16)30632-5.

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