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Interferon Continues to Show Promise as Myelofibrosis Option

Published: Thursday, Jan 04, 2018

Patients with myeloproliferative neoplasm‒associated myelofibrosis (MF) had prolonged treatment duration and improved survival compared with historical controls when treated with pegylated interferon alfa-2a (peg-IFN-alfa-2a), according to findings of a French trial presented at the 2017 ASH Annual Meeting.1

Patients with additional mutations had a median OS of 6.1 years, which trended toward a statistically significant decrement (P =.06). Patients with high-molecular-risk mutations (ASXL1, EZH2, SRSF2, IDH1/2) had a median survival of 4.9 years (P =.068).


  1. Ianotto JC, Chauveau A, Boyer-Perrard F, et al. Long term outcome of patients with MPN-associated myelofibrosis treated with peg-interferon-α2a, a French Intergroup of Myeloproliferative Neoplasms (FIM) study. In: Proceedings from the 59th ASH Annual Meeting and Exposition; December 9-12, 2017; Atlanta, GA. Abstract 323.
  2. Ianotto JC, Boyer-Perrard F, Gyan E, et al. Efficacy and safety of pegylated-interferon a-2a in myelofibrosis: a study by the FIM and GEM French cooperative groups. Br J Haematol. 2013;162(1):783-791. doi:10.1111/bjh.12459.

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