Results from a systemic review and meta-analysis of data collected from nearly 45,000 women treated for cervical precancer found that high-risk HPV posttreatment was a more accurate predictor of treatment failure than incomplete rescission.
Researchers in 5 studies evaluated accuracy data for the combination of the margin status and post- treatment HPV testing. The sensitivity of the 2 combined tests was 99.1% (95% CI, 94.7-100) and specificity was 57.6% (95% CI, 47.4-67.5). The combination was no more sensitive (ratio, 1.04; 95% CI, 0.97-1.11) and significantly less specific (ratio, 0.75; 95% CI, 0.67-0.84) than HPV testing alone.
Arbyn M, Redman CWE, Verdoodt F, et al. Incomplete excision of cervical precancer as a predictor of treatment failure: a systematic review and meta-analysis. Lancet Oncol [published online November 7, 2017]. doi: 10.1016/S1470-2045(17)30700-3.
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