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Involved Margins, High-Risk HPV Post-Treatment Predict Treatment Failure in Cervical Cancer

Jason Harris
Published: Tuesday, Nov 14, 2017

Results from a systemic review and meta-analysis of data collected from nearly 45,000 women treated for cervical precancer found that high-risk HPV posttreatment was a more accurate predictor of treatment failure than incomplete rescission.

Researchers in 5 studies evaluated accuracy data for the combination of the margin status and post- treatment HPV testing. The sensitivity of the 2 combined tests was 99.1% (95% CI, 94.7-100) and specificity was 57.6% (95% CI, 47.4-67.5). The combination was no more sensitive (ratio, 1.04; 95% CI, 0.97-1.11) and significantly less specific (ratio, 0.75; 95% CI, 0.67-0.84) than HPV testing alone.
Arbyn M, Redman CWE, Verdoodt F, et al. Incomplete excision of cervical precancer as a predictor of treatment failure: a systematic review and meta-analysis. Lancet Oncol [published online November 7, 2017]. doi: 10.1016/S1470-2045(17)30700-3.

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Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: 2nd Annual School of Nursing Oncology™Sep 28, 20191.5
Enduring CME activity from the September 4, 2018, Live Webcast: Meeting Unmet Clinical Needs in Cervical Cancer: Paving a New Course in Advanced Disease Settings With Immune-Based StrategiesSep 28, 20191.5
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