William J. Gradishar MD
The triplet combination of HER2-targeted therapy and an aromatase inhibitor (AI) improved progression-free survival (PFS) by more than 5 months compared with the combination of trastuzumab (Herceptin) and an AI in patients with HER2+/HR+ breast cancer.
In the lapatinib/trastuzumab/AI group, 34% of patients experienced grade 3/4 AEs, primarily diarrhea (13%). In the lapatinib/AI group, 32% of patients experienced grade 3/4 AEs, and, again, diarrhea was the most common (6%). Twenty-two percent of patients in the trastuzumab/AI group experienced serious AEs, with ALT and AST increases being the most common (4% each).
Gardishar WJ, Hegg R, Im S, et al. Phase III study of lapatinib (L) plus trastuzumab (T) and aromatase inhibitor (AI) vs T+AI vs L+AI in postmenopausal women (PMW) with HER2+, HR+ metastatic breast cancer (MBC): ALTERNATIVE. J Clin Oncol 35, 2017 (suppl; abstr 1004).
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