Michael Wang, MD
Responses, progression-free and overall survival (OS) with single-agent acalabrutinib (Calquence) remained consistent during long-term follow-up, confirming efficacy in patients with relapsed/refractory mantle cell lymphoma (MCL), according to data presented at the 2018 ASH Annual Meeting.
during the 2018 ASH Annual Meeting, Wang, a professor in the Department of Lymphoma and Myeloma at The University of Texas MD Anderson Cancer Center, discussed the promise of single-agent acalabrutinib in the treatment of patients with relapsed/refractory MCL.
OncLive: Please provide an overview of this study.
: At this meeting, I presented data pertaining to the use of single-agent acalabrutinib in patients with relapsed/refractory MCL. This was the pivotal trial [that led to] the FDA approval, and the initial data were published in Lancet Oncology. At the time of the initial reporting, follow-up was only 15 months. At this meeting, we presented a longer follow-up of over 26 months.
What were the long-term data?
I would like to say the results were very good. The efficacy actually improved with the CR improving to 43%; the ORR remained the same. Long-term toxicity data were even more favorable because all categories of AEs, such as bleeding and rash, decreased over time. Acalabrutinib is a very well-tolerated agent, especially in the longer-term.
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