John L. Marshall, MD
Following the findings of the CALGB 80405 trial, which showed inferior results for patients with right-sided colorectal cancer (CRC) versus those with left-sided CRC—researchers decided to examine molecular variations between left-sided colon tumors and rectal tumors.
at the 2017 Gastrointestinal Cancers Symposium, John L. Marshall, MD, chief, Division of Hematology and Oncology, Medstar Georgetown University Hospital, discussed the results of this analysis and other ongoing efforts to determine the underlying molecular basis for the sidedness issue in colorectal cancer.
OncLive: Can you discuss the rationale behind your research?
For about 15 years, we have had literature that's said right-sided colon cancer behaves worse than left-sided colon cancer. Many ignored that literature until last year when data from a study called CALGB 80405 was presented, which demonstrated a lower survival rate for the right-side, even though both sides received the same treatment.
More importantly, another study showed that there was no difference in clinical outcomes between right versus left. The reason this is important is because doctors are now thinking clinically about if it is a right-sided or left-sided tumor. We should bundle rectal cancer in with left-sided colon cancer for the moment. These two studies determined that we don't need to additionally stratify for rectal cancers. Right now, it's right versus left and we'll continue to figure out what the molecular characteristics are.
What were the main differences between the left-sided and right-sided colorectal cancers?
The most important clinical findings around are the actionable mutations. The one that we're excited about is microsatellite instability, which is more common on the right-side then on the left-side which is true for rectal as well. Additionally, BRAF mutations are more common on the right-side than the left-side.
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