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Molecular Targets Could Be Unraveled for Patients With Non-Driver NSCLC

Gina Columbus @ginacolumbusonc
Published: Thursday, Aug 10, 2017

Millie Das, MD

Millie Das, MD
Within the non–small cell lung cancer (NSCLC) population, patients without known molecular drivers make up the majority of cases, explains Millie Das, MD. However, studies are investigating more regimens to improve the efficacy for these patients.

Das, a clinical assistant professor of medicine – oncology at Standard Medicine, explained the difficulties of the non-driver NSCLC patient population, interesting clinical trials that could reshape therapeutic options, and her belief that these patients do have molecular targets that have yet to be identified.

OncLive: What did you highlight regarding these patients with non-driver NSCLC?

Das: I discussed the treatment options for the majority of our patients who actually don’t have known driver genetic alterations. I talked about the data for chemotherapy and targeted agents—pemetrexed as a frontline option, but also as a maintenance option for our patients. I reviewed the data for bevacizumab, as well, to look at it in the frontline and maintenance settings, and touched upon some of the recent data with necitumumab (Portrazza) and ramucirumab (Cyramza) that have gained FDA approval in the treatment of lung cancer. 

How do you currently use bevacizumab? Can you use it in both the frontline and maintenance settings for a patient?

For bevacizumab, the main thing is the patient selection. In the upfront setting, you would want to think about it for patients with good performance status. We know that the ECOG E-4599 study that looked at bevacizumab examined it in ECOG performance score 0 and 1 patients. These are really fit and likely younger patients. We know that, with patients over the age of 70, there is a higher risk of toxicity—so you want to be mindful of that. For patients who are having ongoing hemoptysis, you’re not going to want to offer that.
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Online CME Activities
TitleExpiration DateCME Credits
Advances in™ Therapies for Patients With ALK-Positive Lung Cancers: More Options…More Decisions…Better OutcomesAug 30, 20191.5
Oncology Briefings™: Treating Advanced NSCLC Without Actionable MutationsAug 30, 20191.0
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