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Neoadjuvant Pembrolizumab Regimen Active in TNBC

Caroline Seymour
Published: Tuesday, Feb 26, 2019

Peter Schmid, MD, PhD

Peter Schmid, MD, PhD

The combination of the PD-1 inhibitor pembrolizumab (Keytruda) and platinum/taxane chemotherapy in the neoadjuvant setting induced high rates of pathologic complete response (pCR) in patients with locally advanced triple-negative breast cancer (TNBC), according to preliminary findings from the phase Ib KEYNOTE-173 trial.1

“The combination of immune checkpoint inhibitors and neoadjuvant chemotherapy is feasible and safe,” said lead study author Peter Schmid, MD, PhD, FRCP, and lead of the Centre for Experimental Cancer Medicine at Barts Cancer Institute, in an interview with OncLive. “We found a very promising, though preliminary, pCR rate in this trial.”

For the trial, Schmid and researchers set out to establish the safety, tolerability, and recommended phase II dose of neoadjuvant therapy as well as to understand which chemotherapy backbone induced the highest rates of response when paired with pembrolizumab.

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Community Practice Connections™: PARP Inhibition in Breast Cancer: Practical Methods to Interpret and Apply the Evidence for Your PatientsAug 30, 20191.5
Provider and Caregiver Connection™: Addressing Patient Concerns in the Management of Premenopausal Breast CancerAug 31, 20192.0
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