Lajos Pusztai, MD, DPhil
Investigators at Yale Cancer Center believe that a statistical model that combines multiple variables such as tumor size and lymph-node status into a single score can improve patient selection for breast cancer clinical trials and produce stronger results.
With a sample size of 800, the respective power associated with scenario 1 was 0.87, compared with 0.84 in scenario 2, 0.80 in scenario 3, and 0.76 in scenario 4. Investigators emphasized these changes in power occurred even though all patients met eligibility criteria based on tumor size and nodal status.
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