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Nivolumab/Ipilimumab Combo Shows Durable Activity in Small Cell Lung Cancer

Angelica Welch
Published: Thursday, Jul 20, 2017

Matthew D. Hellmann, MD

Matthew D. Hellmann, MD
There are limited options for patients with small cell lung cancer after first-line platinum-based chemotherapy. In a search for treatment, researchers designed the CheckMate-032 trial to evaluate multiple regimens of nivolumab (Opdivo) plus ipilimumab (Yervoy), which showed signs of tolerability and efficacy.

, lead author Mathew D. Hellmann, MD, medical oncologist, Memorial Sloan Kettering Cancer Center, discussed the first report of the randomized expansion cohort from CheckMate-032.

OncLive: Please provide an overview of the study.

Hellmann: CheckMate-032 was a phase I/II study of patients with small cell lung cancer who were treated with nivolumab with or without ipilimumab. The reason for the study was that, unfortunately, outcomes and treatment options for patients with small cell lung cancer are poor and new treatment options are desperately needed. There was an initial cohort of patients in this study of about 150 patients with small cell lung cancer who are were assigned to receive nivolumab or ipilimumab, and there were some early signs promising of efficacy. And as a result of that initial study, nivolumab with or without ipilimumab was added to the NCCN guidelines last year. 
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