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Novel Agent Active Across Heavily Pretreated HER2+ Tumors

Jason M. Broderick @jasoncology
Published: Friday, Nov 16, 2018

Murali Beeram, MD

Murali Beeram, MD

The novel bispecific antibody ZW25 induced a disease control rate (DCR) of 82% in heavily pretreated patients across several HER2-positive tumor types, according to phase I study results presented at the 2018 EORTC-NCI-AACR Molecular Targets and Cancer Therapeutics Symposium.

At the EORTC-NCI-AACR Symposium, meeting co-chair Antoni Ribas, MD, PhD, professor of medicine, surgery, and molecular and medical pharmacology at the University of California, Los Angeles, who was not an author on the study, commented, “Although these are early results on a small number of patients, they suggest that this new HER2 targeted antibody can have an effect on difficult-to-treat cancers that have either failed to respond to previous therapies or have recurred. We look forward to further results from this study, as well as the further studies that are planned.”
Beeram, M. Single agent activity of ZW25, a HER2-targeted bispecific antibody, in HER2-expressing gastroesophageal and other cancers. Presented at: 30th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics; November 13-16, 2018; Dublin, Ireland. Abstract 6.

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