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Novel Combinations Key to Advancing HR+ Breast Cancer Care

Gina Columbus @ginacolumbusonc
Published: Tuesday, Dec 27, 2016

What is really going to happen that will be exciting is the BELLE-2 trial—even though it’s a different class of drugs. It does point to the right platform for looking at molecular alterations in the current state of the cancer for predicting what agents someone will respond to. We will be sorting out the platform technology for assessing genetic mutation status and combining not just CDK4/6 inhibitors by themselves or with endocrine therapy, but looking at those endocrine-resistant mechanisms and the molecular pathways that compensate or contribute to that resistance and having targeted agents that go after those pathways.
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Community Practice Connections™: How Do We Leverage PARP Inhibition Strategies in the Contemporary Treatment of Breast Cancer?May 31, 20191.5
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