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Olaparib Improves Radiographic PFS in HRR-Mutant mCRPC

Gina Columbus @ginacolumbusonc
Published: Wednesday, Aug 07, 2019

Jose Baselga, MD

José Baselga, MD

Olaparib (Lynparza) demonstrated a statistically significant and clinically meaningful improvement in radiographic progression-free survival (rPFS) compared with enzalutamide (Xtandi) or abiraterone acetate (Zytiga) in patients with metastatic castration-resistant prostate cancer (mCRPC) who harbor a homologous recombination repair (HRR) gene mutation and have progressed on prior therapy with either androgen receptor (AR) inhibitor, meeting the primary endpoint of the phase III PROfound trial (NCT02987543).1
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