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PARP Inhibition Enhanced Through Combination in Ovarian Cancer

Angelica Welch
Published: Friday, Jan 26, 2018

Mansoor Raza Mirza, MD

Mansoor Raza Mirza, MD
The combination of a PARP inhibitor and a VEGF inhibitor is a logical strategy in the treatment of relapsed patients with platinum-sensitive epithelial ovarian cancer, according to Mansoor Raza Mirza, MD.

, Mirza, who is the chief oncologist at Copenhagen University Hospital and lead author of the ENGOT-OV24/AVANOVA1 trial, discussed the initial findings and next steps for the promising niraparib plus bevacizumab combination in ovarian cancer, as well as overall advances with PARP inhibitors in the field.

OncLive: Please discuss the combination of niraparib and bevacizumab.

Mirza: Previously, we presented the results of the phase III trial with niraparib. It showed tremendous benefit for patients who received niraparib versus placebo, and it is already labeled by the FDA for treatment in the maintenance setting. The next step will be to further improve the treatment of our patients, but the question is, “Do these patients have to receive a cytotoxic chemotherapy every time they relapse?”
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Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: ASCO Direct™ Highlights – 2019 Official Annual Meeting ReviewAug 30, 20201.5
Community Practice Connections™: Advances in Ovarian Cancer: Evolving Applications for PARP Inhibitors, Immunotherapy & Beyond!Aug 30, 20201.5
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