Scott J. Antonia, MD, PhD
A combination checkpoint blockade with the PD-L1 inhibitor durvalumab and the anti–CTLA-4 agent tremelimumab induced a response rate of 23% in patients with advanced non–small cell lung cancer (NSCLC), according to phase Ib data published in The Lancet Oncology
Antonia S, Goldberg SB, Balmanoukian A, et al. Lancet Oncol. Safety and antitumor activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicenter, phase 1b study [published online February 5, 2016]. Lancet Oncol. doi:10.1016/S1470-2045(15)00544-6.
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