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Pembrolizumab Plus Epacadostat Active in RCC

Danielle Bucco
Published: Wednesday, Aug 02, 2017

Dr. Primo Lara

Primo N. Lara Jr, MD
The combination of the PD-1 inhibitor pembrolizumab (Keytruda) and the IDO-inhibitor epacadostat induced a response rate of 47% in patients with advanced renal cell carcinoma (RCC), according to results from the phase I/II KEYNOTE-037 study presented at the 2017 ASCO Annual Meeting.

during ASCO, Primo N. Lara Jr, MD, an associate director for Translational Research and co-leader of the Cancer Therapeutics Program at the UC Davis Comprehensive Cancer Center, discussed the KEYNOTE-037 pembrolizumab/epacadostat findings in patients with advanced RCC, and how the combination could change treatment in this population.

OncLive: Can you give an overview of the study investigating epacadostat and pembrolizumab?

Lara: The epacadostat/pembrolizumab trial was a phase Ib/II trial testing the IDO inhibitor epacadostat in combination with the PD-1 inhibitor pembrolizumab in a variety of solid tumors. The subset that we presented at ASCO this year was in metastatic renal cell carcinoma.
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Community Practice Connections™: New Directions in Advanced Cutaneous Squamous Cell Carcinoma: Emerging Evidence of ImmunotherapyAug 13, 20191.5
Clinical Practice Connections™: New York Advanced Practice CollaborativeNov 15, 20191.25
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