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Reduced GVHD Prophylaxis Possible in Pediatric Acute Leukemia

Jason Harris
Published: Monday, Dec 04, 2017

Muna Qayed, MD

Muna Qayed, MD
The risk for graft-vs-host disease (GVHD) is low in children aged 2 to 12 years with acute leukemia, suggesting these patients may be good candidates for reduced preventative measures.

Overall survival (OS) was 81% (95% CI, 78-85) at 1 year posttransplant. Transplant-related mortality was 2% (95% CI, 1-3) at 100 days and 4% (95% CI, 3-6) at 1 year. By multivariate analyses, there was no difference in OS, relapse-free survival, or leukemia-free survival between the age groups.
Qayed M, Wang T, Hemmer MT, et al. Influence of age on acute and chronic GVHD in children receiving HLA-identical sibling BMT for acute leukemia: implications for prophylaxis [published online November 16, 2017]. Biol Blood Marrow Transplant. doi: 10.1016/j.bbmt.2017.11.004.

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