Scott Z. Fields, MD
The combination of regorafenib (Stivarga) and nivolumab (Opdivo) will be compared with regorafenib alone in a phase III trial of patients with microsatellite stable (MSS) colorectal cancer (CRC), following encouraging phase Ib findings of the REGONIVO study.1
Further biomarker analyses are ongoing for the study.
- Bayer, Bristol-Myers Squibb and Ono Pharmaceutical Enter into a Clinical Collaboration Agreement to Investigate Stivarga (Regorafenib) and Opdivo (Nivolumab) as Combination Therapy in Patients With Metastatic Colorectal Cancer. Bayer. Published July 18, 2019. https://bit.ly/2SnCeyX. Accessed July 18, 2019.
- Fukuoka S, Hara H, Takahashi N, et al. Regorafenib plus nivolumab in patients with advanced gastric (GC) or colorectal cancer (CRC): an open-label, dose-finding, and dose-expansion phase Ib trial (REGONIVO, EPOC1603). J Clin Oncol. 2019;37(suppl; abstr 2522). doi: 10.1200/JCO.2019.37.15_suppl.2522.
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