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Rhabdomyosarcoma Cell Origin Affects Treatment and Survival of Pediatric Patients

Danielle Bucco
Published: Thursday, Feb 08, 2018

Mark E. Hatley, MD

Mark E. Hatley, MD
Rhabdomyosarcoma, a common form of soft tissue sarcoma in pediatric patients, can originate from aberrant development of nonmyogenic cells, according to research conducted at St. Jude Children’s Research Hospital.


Specifically, investigators showed that rhabdomyosarcoma originates from immature progenitors lining the blood vessels and hedgehog pathway activation. The blood vessels occupy the space between the muscle fibers that are found throughout the body, according to Mark E. Hatley, MD. Previously, researchers thought that this type of cancer was caused from immature muscle cells.

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