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Sacituzumab Govitecan Shows Early Promise in Urothelial Carcinoma

Brandon Scalea
Published: Monday, Mar 04, 2019

Scott Tagawa, MD

Scott Tagawa, MD

Sacituzumab govitecan seemed to effectively achieve its goal of delivering the potent toxin SN-38 to tumor cells and sparing normal cells in patients with advanced urothelial carcinoma, said Scott T. Tagawa, MD.

In results of a phase I/II study (NCT01631552) presented at the 2019 Genitourinary Cancers Symposium, the antibody-drug conjugate (ADC) demonstrated clinical activity in patients with advanced urothelial carcinoma, including those who were previously treated with checkpoint inhibition and those with visceral disease.

In 45 patients, the objective response rate (ORR) was 31.1% (95% CI, 18.2-46.6), including a complete response rate of 4% and a partial response rate of 27%. Median progression-free survival (PFS) and overall survival (OS) were 7.3 months (95% CI, 5.0-10.7) and 16.3 months (95% CI, 9.0-31.0), respectively.

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