John Strickler, MD
Effective therapies are being tailored to small subsets of patients with certain molecular abnormalities in their tumors, but the next steps for research in metastatic colorectal cancer (mCRC) are to turn these incremental benefits into long-term survival, said John Strickler, MD.
As treatment options become more widespread in this space, there is also a greater focus on quality of life. In the phase II ReDOS trial, investigators evaluated a dose-escalation strategy of regorafenib (Stivarga) beginning at 80 mg and ending at 160 mg daily for patients with mCRC. Regorafenib is an active TKI, but it can come with significant toxicities, such as hand-foot syndrome and fatigue.
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