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Study Suggests Superiority of Functional Imaging in Assessing Sarcoma Outcomes

Allie Strickler @Alliejayes
Published: Monday, Sep 26, 2016

Laurence H. Baker, DO

Laurence H. Baker, DO

A comparison of anatomic and functional imaging in the assessment of clinical outcomes in patients with Ewing sarcoma has shown that FDG-PET, assessed by PERCIST criteria, was superior in predicting clinical benefits and identifying responses, according to a study published in the Journal of Clinical Oncology.

The imaging criteria comparison included PERCIST 1.0 for functional imaging (FDG-PET). Anatomic imaging included WHO criteria on the basis of independent assessment and on the basis of local site measurements, RECIST criteria on the basis of independent assessment, and volumetric criteria on the basis of measurements done by a central radiology group who were blinded to the PET results and clinical outcomes.

“The standard criteria are RECIST 1.1 and WHO. Those are anatomic measurements that look at either, in the case of WHO, the perpendicular diameters of lesion, or in the case RECIST, the single diameter of the sum of the unidimensional measurements on anatomic imaging,” Laurence H. Baker, DO, a professor of Medical Oncology at the University of Michigan Medical School, said in an interview with OncLive.
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