The addition of bevacizumab (Avastin) to TAS-102 (trifluridine/tipiracil; Lonsurf) reduced the risk of disease progression or death by 55% compared with TAS-102 alone in patients with chemorefractory metastatic colorectal cancer (mCRC), according to findings from an investigator-initiated, open-label, randomized phase II trial published in The Lancet Oncology
second-line treatment in patients who have progressed on a first-line bevacizumab-containing regimen.
Pfeiffer P, Yilmaz M, Möller S, et al. TAS-102 with or without bevacizumab in patients with chemorefractory metastatic colorectal cancer: an investigator-initiated, open-label, randomised, phase 2 trial. Lancet Oncol. 2020;21(3):412-420. doi: 10.1016/S1470-2045(19)30827-7.
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