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Tisagenlecleucel Responses in Pediatric ALL Sustained With Longer Follow-up

Jason Harris
Published: Thursday, Feb 01, 2018

Shannon L. Maude, MD, PhD

Shannon L. Maude, MD, PhD
At a median follow-up of 13.1 months, tisagenlecleucel (Kymriah) induced an overall remission rate of 81% in children and young adults with relapsed/refractory B-cell acute lymphoblastic leukemia (ALL).1

Among all infused patients, the relapse-free survival rate was 75% at 6 months and 64% at 9 and 12 months. OS was 89% at 6 months and 79% at 9 and 12 months. Median OS was 16.6 months.

References

  1. Maude SL, Laetsch TW, Buechner J, et al. Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia. N Engl J Med. 2018; 378:439-448.
  2. Pulsipher M, Buechner J, Grupp SA, et al. Global registration trial of efficacy and safety of CTL019 in pediatric and young adult patients with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL): update to the interim analysis. Presented at 2017 SOHO Annual Meeting. Abstract ALL-152.

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