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TP53 Variants Increase Risk for Pediatric ALL, Adverse Treatment Outcomes

Jason Harris
Published: Friday, Jan 12, 2018

Jun J. Yang, PhD

Jun J. Yang, PhD
Children with TP53 pathogenic variants were more likely to both develop acute lymphoblastic leukemia (ALL), as well as secondary cancers later on, according to an analysis of 3801 Children with newly diagnosed B-cell ALL enrolled in 2 consecutive Children’s Oncology Group trials.

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Qian M, Cao X, Devidas M, et al. TP53 germline variations influence the predisposition and prognosis of B-cell acute lymphoblastic leukemia in children [published online January 4, 2018]. J Clin Oncol doi: 10.1200/JCO.2017.75.5215.

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