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Trametinib Emerges as New Standard Option for Recurrent, Low-Grade Ovarian Cancer

Published: Thursday, Oct 03, 2019

David Gershenson, MD, of the University of Texas MD Anderson Cancer Cente

David Gershenson, MD

Treatment with the MEK inhibitor trametinib (Mekinist) significantly improved progression-free survival (PFS) and led to a strong trend toward improved overall survival (OS) in recurrent, low-grade serous ovarian cancer, a randomized trial showed.

Median PFS improved from 7.2 months with current standard-of-care (SOC) options to 13.0 months with trametinib. OS increased by 8 months, but just missed achieving statistical significance (P = .054).

More than four times as many patients achieved objective responses with the MEK inhibitor, and responses last more than twice as long, as reported at the 2019 ESMO Congress.

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