Sara M. Tolaney, MD, MPH
Trastuzumab (Herceptin) remains a standard of care in the neoadjuvant and adjuvant treatment settings for patients with HER2-positive breast cancer. Sara M. Tolaney, MD, is trying to determine whether combination regimens with additional HER2-directed therapies or alternative therapies could improve responses in this patient population without added toxicities.
“One approach I have taken is to use TCH in patients with cardiac risk factors and AC-TH in most other patients,” she said.
Trastuzumab in Combination
“While outcomes for HER2-positive disease have dramatically improved with the addition of trastuzumab, approximately 15% of women with early stage HER2-positive disease still recur, so there is a need to do better,” Tolaney said.
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