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Update Sustains OS Benefit of Chemohormonal Therapy in High-Volume Prostate Cancer

Jason Harris
Published: Friday, Feb 02, 2018

Prostate Cancer
Adding docetaxel to androgen-deprivation therapy (ADT) improved overall survival (OS) by nearly 17 months in men with high-volume metastatic hormone-sensitive prostate cancer. Investigators for the multicenter phase III CHAARTED trial noted that the survival benefit did not extend to men with low-volume disease.1

= .11).

References

  1. Kyriakopoulos CE, Chen Y, Carducci MA, et al. Chemohormonal therapy in metastatic hormone-sensitive prostate cancer: long-term survival analysis of the randomized phase III E3805 CHAARTED trial [published online January 31, 2018]. J Clin Oncol. doi: 10.1200/JCO.2017.75.3657.
  2. Sweeney CJ, Chen YH, Carducci M, et al. Chemohormonal therapy in metastatic hormone-sensitive prostate cancer. N Engl J Med. 2015; 373:737-46. doi: 10.1056/NEJMoa1503747.

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