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Update Sustains Tisagenlecleucel Activity in Pediatric ALL

Published: Wednesday, Sep 20, 2017

Michael Pulsipher, MD

Michael Pulsipher, MD
Tisagenlecleucel (Kymriah), the first FDA-approved CAR T-cell therapy, induced a complete remission (CR) with complete or incomplete hematologic recovery in 83% of pediatric, adolescent, and young adult patients with acute lymphoblastic lymphoma (ALL).

Patient quality of life improved from baseline to 3 months by 2 different assessment instruments.
Pulsipher M, Buechner J, Grupp SA, et al. Global registration trial of efficacy and safety of CTL019 in pediatric and young adult patients with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL): update to the interim analysis. Presented at 2017 SOHO Annual Meeting. Abstract ALL-152.

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