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Frontline treatment with acalabrutinib and bendamustine/rituximab (BR) improved PFS over BR alone in older patients with mantle cell lymphoma.

Frontline Acalabrutinib/BR Regimen Significantly Improves PFS in Mantle Cell Lymphoma

The combination of sonrotoclax and zanubrutinib had a tolerable safety profile and led to durable responses in relapsed/refractory CLL/SLL.

Sonrotoclax Plus Zanubrutinib Is Safe, Efficacious in Relapsed/Refractory CLL/SLL

Linvoseltamab induced durable responses in patients with relapsed or refractory multiple myeloma, including those with high-risk features.

Linvoseltamab Elicits Deep, Durable Responses in R/R Multiple Myeloma

Patients with essential thrombocythemia who progressed to myelofibrosis had longer duration of disease, higher white blood cell counts, and lower hemoglobin levels at enrollment.

Prospective Analysis Highlights Patterns of Progression to Myelofibrosis Following Essential Thrombocythemia Diagnosis

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The FDA placed a partial clinical hold on a phase 1 trial evaluating YL202 in select patients with advanced non–small cell lung cancer or breast cancer.

FDA Places Partial Clinical Hold on Phase 1 Trial of YL202 in Advanced NSCLC and Breast Cancer

 
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Advances in the Treatment and Management of Myelodysplastic Syndrome (MDS): The Role of Oral HMAs

Managing AEs Associated with HMA Treatment

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Join Dr. Guillermo Garcia-Manero in this OncLive Insights program as he delves into the latest advancements in the treatment of myelodysplastic syndrome (MDS), with a specific focus on the emerging role of oral hypomethylating agents (HMAs).

This page is funded by Taiho Oncology, Inc. The faculty and publisher are solely responsible for this content. Taiho does not recommend or endorse the use of its products other than as described in the approved labeling. The content of this page is not medical advice and does not replace independent medical judgment.

Join Dr. Guillermo Garcia-Manero in this OncLive Insights program as he delves into the latest advancements in the treatment of myelodysplastic syndrome (MDS), with a specific focus on the emerging role of oral hypomethylating agents (HMAs). In this episode, gain insights about MDS risk stratification and prognosis, and why it is important to treat early.

Diagnosing and Managing Myelodysplastic Syndrome

The role of HMAs in the treatment of patients with intermediate- and high-risk MDS.

Treating Intermediate- and High-Risk MDS

Guillermo Garcia-Manero, MD, provides a high-level overview of the effectiveness of oral HMA agents in the treatment of intermediate- and high-risk MDS.

Available and Emerging Oral HMAs

An expert discusses the real-world impact of hypomethylating agents for the treatment of patients with MDS.

Real-World Use for Oral HMAs

A review of the benefits of oral HMA treatments in the management of MDS, and the impact on a patient's quality of life.

The Impact of Oral HMA Treatment Options on QOL

An expert discusses data supporting the use of HMAs in the treatment of lower-risk MDS.

The Role for HMAs in Lower-Risk MDS

An overview of how HMAs are being used to treat CMML and their use in combination with other therapies for patients with AML.

Treating CMML and AML with HMAs

Guillermo Garcia-Manero, MD, reviews potential serious and common adverse effects associated with HMA treatments, shares tips for patient education to help manage these AEs, and discusses if and when a dose reduction or discontinuation may be necessary.

Insights Video Series

Managing AEs Associated with HMA Treatment

EP: 1.Diagnosing and Managing Myelodysplastic Syndrome

EP: 2.Treating Intermediate- and High-Risk MDS

EP: 3.Available and Emerging Oral HMAs

EP: 4.Real-World Use for Oral HMAs

EP: 5.The Impact of Oral HMA Treatment Options on QOL

EP: 6.The Role for HMAs in Lower-Risk MDS

EP: 7.Treating CMML and AML with HMAs

EP: 8.Managing AEs Associated with HMA Treatment

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