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Consuelo Bertossi, MD, discusses the role of TP53 mutations and their prognostic significance in chronic lymphocytic leukemia.

Dr Bertossi on the Prognostic Role of TP53 Mutations in CLL

Michael R. Grunwald, MD, FACP, discusses disease progression in patients with low-risk myelofibrosis enrolled in the prospective MOST study.

Dr Grunwald on the Rates of Disease Progression in Low-Risk Myelofibrosis  

The combination of zanubrutinib, obinutuzumab, and venetoclax was safe and well-tolerated in older patients with untreated mantle cell lymphoma.

Zanubrutinib Plus Obinutuzumab/Venetoclax Is Safe, Elicits Responses in Older Patients With Untreated MCL

Earlier use of acalabrutinib was associated with improved survival in patients with chronic lymphocytic leukemia.

Earlier Use of Acalabrutinib Associated With Improved Survival in CLL 

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Kristi Rosa joined MJH Life Sciences in 2016 and has since held several positions within the company. She helped launch the rapidly growing infectious disease news resource 

. Prior to working at the company, she served as lead copywriter and marketing coordinator at The Strand Theater. Email: krosa@onclive.com

The FDA has approved blinatumomab (Blincyto) for use in select patients with CD19+ Ph– B-cell precursor acute lymphoblastic leukemia in the consolidation phase.

FDA Approves Blinatumomab for CD19+ B-ALL in the Consolidation Phase

The FDA had approved durvalumab plus, followed by single-agent durvalumab, for dMMR primary advanced or recurrent endometrial cancer.

FDA Approves Durvalumab Plus Chemotherapy for dMMR Primary Advanced or Recurrent Endometrial Cancer

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My Treatment Approach: Targeting Genetic Alterations in Tumors: Clinical Scenarios and Precision Oncology Approaches

Clinical

Overview of Tumor agnostic Treatment: Considerations for NGS Testing in Solid Tumors 

Videos

Insights into integrating tumor agnostic therapies for actionable genetic alterations across solid tumors. Renowned experts Dr. Vivek Subbiah, Dr. Karisa Schreck, and Dr. Rimas Lukas delve into pivotal clinical cases showcasing the identification and targeted treatment of BRAF and RET fusions. The in-depth discussion spotlights practical strategies for NGS testing, overcoming barriers to adoption, efficacy and safety data from landmark trials, sequencing of therapies, and the evolving landscape of precision oncology beyond current approvals. Gain invaluable clinical pearls for optimizing patient outcomes with tumor agnostic targeted agents in the community setting.

Experts discuss the importance of NGS testing for identifying actionable alterations like RET fusions in solid tumors and when to consider testing. 

Dr. Lukas presents a case of a young man with a BRAF-fused brain tumor treated with a MEK inhibitor. Explored tailored therapy targeting the underlying genetic alteration. 

Targeting RET Fusion in Brain Tumor

Dr. Schreck brings forward a compelling case of a teenage female with BRAF V600E mutant ganglioglioma. Witness how the identification of this specific genetic alteration paved the way for treated with targeted therapy.

BRAF V600E Mutant Ganglioglioma 

Experts discuss the challenges in adopting targeted therapies like BRAF/MEK inhibitors for BRAF-altered gliomas and gangliogliomas and strategies to facilitate their integration into practice.

Challenges in Adopting Targeted Therapies for BRAF Alterations

Dr. Subbiah and Dr. Lukas review the efficacy and safety data from key clinical trials like ROAR and MATC evaluating tumor agnostic therapies across different tumor types.

Efficacy and Safety of Tumor Agnostic Therapies  

Dr. Subbiah presents a pancreatic cancer case with PRKARA1A- RET fusion treated with selpercatinib in a clinical trial. 

PRKAR1A-RET Fusion in Pancreatic Cancer: Unlocking New Therapeutic Frontiers 

The panel discusses the impact of tumor agnostic approvals like BRAF/MEK inhibitors on the treatment landscape, unmet needs address and sequencing therapies like RET inhibitors in cancers like pancreatic cancer. 

Impact and Positioning of Tumor Agnostic Approvals  

The panelists provide their perspective on best practices for keeping up with the rapidly evolving RET fusion landscape and unmet needs to be addressed by future RET-targeted therapies beyond lung cancer. 

Future Outlook for RET Fusion-Targeted Therapies 

Overview of Tumor agnostic Treatment: Considerations for NGS Testing in Solid Tumors

EP: 1.Overview of Tumor agnostic Treatment: Considerations for NGS Testing in Solid Tumors

EP: 2.Targeting RET Fusion in Brain Tumor

EP: 3.BRAF V600E Mutant Ganglioglioma

EP: 4.Challenges in Adopting Targeted Therapies for BRAF Alterations

EP: 5.Efficacy and Safety of Tumor Agnostic Therapies

EP: 6.PRKAR1A-RET Fusion in Pancreatic Cancer: Unlocking New Therapeutic Frontiers

EP: 7.Impact and Positioning of Tumor Agnostic Approvals

EP: 8.Future Outlook for RET Fusion-Targeted Therapies

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