Experts Discuss Common AEs With EGFR TKIs

EP: 1.Emily Skotte, MSN on Rash Management in Patients Treated With EGFR TKIs

EP: 2.Dr. Cass on Managing Diarrhea in Patients Treated With EGFR TKIs

EP: 3.Dr. Piotrowska on the Management of Paronychia Associated With EGFR TKIs

EP: 4.Best Practices for Managing EGFR Tyrosine Kinase Inhibitor–Related Adverse Events

EP: 5.Experts Discuss Management of Skin and Mouth TRAEs Associated With EGFR TKIs

EP: 6.Experts Discuss the Risk of Skin Toxicities Associated With EGFR TKIs

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EP: 7.Experts Discuss Common AEs With EGFR TKIs

EP: 8.Experts Discuss the Safety Profile of Mobocertinib in EGFR Exon 20–Mutated Advanced NSCLC

EP: 9.Experts Discuss How to Address Cardiac-Related Toxicities With EGFR TKIs

EP: 10.Experts Discuss the Management of Paronychia When Treating Patients with EGFR TKIs

EP: 11.Experts on the Management of Diarrhea Associated With EGFR TKIs

Zosia Piotrowska, MD, Christine Lovly, MD, PhD, and Amanda Cass, PharmD, BCPS, BCOP discuss common adverse effects (AEs) with EGFR TKIs.

Zosia Piotrowska, MD, is a clinical researcher and lung cancer medical oncologist, Massachusetts General Hospital Cancer Center. Christine Lovly, MD, is an associate professor of medicine, Division of Hematology-Oncology, an Ingram associate professor of Cancer Research, co-leader, the Translational Research and Interventional Oncology Program, Vanderbilt University Medical Center, Vanderbilt Ingram Cancer Center. Amanda Cass, PharmD, BCPS, is a clinical pharmacist, the Thoracic Oncology Clinic, Vanderbilt University Medical Center.

Lovly, Piotrowska, and Cass, explain that the inhibition of EGFR wild-type, which is commonly expressed in the skin, mucous membranes, and the gut, can lead to many of the skin toxicities associated with EGFR TKIs.

Moreover, the 3 experts discuss the adverse effects specifically associated with the use of osimertinib (Tagrisso). Osimertinib can lead to nail bed changes, rash, and sun sensitivity. Additionally, it is important to take up-front preventative measures to attempt to mitigate these skin toxicities.