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MammaPrint high 2 HR-positive/HER2-negative early-stage breast cancer exhibited a heightened immune active state.

MammaPrint High 2 Indication Could Be Predictive Biomarker for Immunotherapy in HR+/HER2– Early Breast Cancer

Linvoseltamab elicited outcomes equivalent to those seen with teclistamab in patients with triple-class exposed relapsed/refractory multiple myeloma.

Linvoseltamab Generates Efficacy Similar to That Seen With Teclistamab in R/R Myeloma

Dostarlimab plus carboplatin and paclitaxel improved PFS and OS in dMMR/MSI-H primary advanced or recurrent endometrial cancer. 

Dostarlimab With Carboplatin/Paclitaxel Shows Survival Benefits in dMMR/MSI-H Endometrial Cancer

Pembrolizumab and platinum-based therapy elicited safe and efficacious outcomes in penile squamous cell carcinoma.

Pembrolizumab With Platinum-Based Therapy is Safe and Efficacious in PSCC

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Anthony Hunter, MD, discusses JAK inhibitor selection in myelofibrosis in the first line and beyond. 

Factors for JAK Inhibitor Selection in Myelofibrosis in the First Line and Beyond

A case study showed community oncology practices emerged as the preferred site of service for cancer treatment.

New Case Study Highlights Community Oncology Practices as Preferred Site of Service Over Hospitals and Academic Centers

Data from a large prospective cohort study reveal that a polygenic risk score has the potential to predict survival outcomes in patients with breast cancer. 

Study Shows Polygenic Risk Score (PGS) Could Predict Breast Cancer Survival Outcomes

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Post-Conference Perspectives: Recent Advances in the Management of Chronic GvHD

Videos

Preet M. Chaudhary, MD, PhD and Noah Merin, MD, PhD discuss the chronic graft versus host disease treatment landscape, covering first- and second-line treatments and emergent trial data.

Preet M. Chaudhary, MD, PhD and Noah Merin, MD, PhD review how chronic GvHD is diagnosed, the different types of chronic GvHD, and key risk factors for the disease.

The Chronic GvHD Landscape:  Risk Factors and Diagnosis 

Expert clinicians discuss first-line treatment methodologies for chronic GvHD, with a focus on tailoring treatments to the patient. 


First-line Treatment for Patients with Chronic GvHD

Dr. Merin defines steroid refractory chronic GvHD, explains how to determine when patients become steroid-refractory and discusses treatment approach for this population. 


Defining and Managing Steroid Refractory Chronic GvHD

Dr. Chaudhary introduces data supporting the use of ruxolitinib as a first-line option in patients with steroid-refractory chronic GvHD. 


Role of Ruxolitinib in Steroid-Refractory Chronic GvHD

Dr. Merin describes the mechanisms of action of ruxolitinib, ibrutinib, and belumosudil and shares clinical pearls for community oncologists on methods for achieving response with these agents.

Understanding Mechanisms of Action: Ruxolitinib, Ibrutinib, and Belumosudil

A brief review of the key efficacy data for two treatment options, Ibrutinib and Belumosudil, in patients with chronic GvHD.

Key Efficacy Data of Ibrutinib and Belumosudil in Steroid-Refractory Chronic GvHD Patients

Discussion centered around real-world data following the approval of ruxolitinib as a treatment option for patients with chronic GvHD as well as discussing  treatment selection for patients with chronic GvHD, with special consideration for treatment sequencing.

Real World Data on the Use of Ruxolitinib and Treatment Selection in chronic GvHD

Dr. Chaudhary and Dr. Merin discuss potential areas for exploration and unmet needs in the chronic GvHD treatment landscape. 

Future Directions in Chronic GvHD

First-line Treatment for Patients with Chronic GvHD

EP: 1.The Chronic GvHD Landscape: Risk Factors and Diagnosis

EP: 2.First-line Treatment for Patients with Chronic GvHD

EP: 3.Defining and Managing Steroid Refractory Chronic GvHD

EP: 4.Role of Ruxolitinib in Steroid-Refractory Chronic GvHD

EP: 5.Understanding Mechanisms of Action: Ruxolitinib, Ibrutinib, and Belumosudil

EP: 6.Key Efficacy Data of Ibrutinib and Belumosudil in Steroid-Refractory Chronic GvHD Patients

EP: 7.Real World Data on the Use of Ruxolitinib and Treatment Selection in chronic GvHD

EP: 8.Future Directions in Chronic GvHD

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